National Route 40 is the longest in the country, crossing it from south to north through 5224 km.

National Route No. 40 is an Argentine highway whose route extends from Cabo Vírgenes, Santa Cruz to the border with Bolivia in the city of La Quiaca, in Jujuy.
This road runs parallel to the Andes Mountains, including nearby sections or through several national parks.
It is the longest in the country, crossing it from south to north and runs through several of the tourist regions and the most important attractions of its territory.
The route covers 5224 km: it starts at sea level, crosses 20 national parks, 18 important rivers, connects 27 mountain passes and climbs at 5000 meters above sea level in the Abra del Acay in Salta.
Like the legendary US Route 66 UU., Route 40 is an emblem of Argentina. This road crosses 11 provinces: Santa Cruz, Chubut, Río Negro, Neuquén, Mendoza, San Juan, La Rioja, Catamarca, Tucumán, Salta and Jujuy.
Through this road you can access El Calafate, near the Perito Moreno Glacier, Puelo Lake, El Bolsón, Bariloche, Chos Malal, the Wine Route in the provinces of Mendoza and San Juan, dinosaur fossil sites in the Province from San Juan, hot springs in Catamarca, the Ruins of Quilmes, the Calchaquí Valleys and the Puna.